Spanish researchers have discovered a new signaling pathway regulated by VAV2 molecules in mice, which plays a key role in regulating muscle mass. When it is highly activated, it helps build a lot of muscle, and if it is not very active, it slows down the process.
Recent research, published in Nature Communications, Determine a new Biological pathway,by VAV2 molecule, It determines muscle We can develop.This work has been done by Xosé Bustelo, From Cancer Research Center (China Investment Corporation) And the team leader of the Cancer Network Biomedical Research Center (Siberon).
In addition to performing functions related to our body movements and performing power movements, our muscles also play an important role in sports. Metabolic balance Our body.
The development of the right amount of muscle depends on Hormones, Who gave orders so that their formation and increase Muscle mass over time.
Therefore, changes in these substances or their signal transduction pathways can determine abnormal muscle growth, reduction or atrophy. However, we still know very little about these biological processes.
To achieve this discovery, the research team generated two types of genetically modified mice that changed the biological activity of VAV2. “With the first experimental model expressing the activated form of this molecule, we have seen mice produce a lot of muscle,” Bustelo explained.
In contrast, the second mice expressing the low-active form of VAV2 had very low muscle mass. Therefore, this molecule must play a key role in determining the molecular mass of our body,” he added.
“Subsequent studies have shown that the role of VAV2 is to promote the action of insulin and related hormones in muscle cells. In turn, this prompted us to discover the specific mechanism by which it exerts this function.” Sonia Luo, the first author of this work Riggs Fernandez added.
“VAV2 seems to work, so it’s like Popeye’s spinach: when it’s highly activated, it helps build a lot of muscle, and when it’s not very active, it leads to a decrease in muscle mass.” The researchers continued. .
More muscle, less obesity
The authors were also able to see that mice with greater muscle mass showed healthier characteristics and did not develop obesity when a high-fat diet was added. In contrast, mice with less muscle due to low VAV2 activity became obese spontaneously, and when a high-fat diet was added, they weighed much more than control animals.
In addition, rodents have also experienced problems commonly associated with obesity, such as diabetes and metabolic syndrome. “These data remind us of the fundamental role that muscles play in maintaining adequate long-term metabolic balance in the body,” Bustelo revealed.
Rodríguez Fernández concluded: “They also showed that being slim is obviously good for maintaining our health, but if weight loss comes at the cost of losing muscle mass, this is not the case.”
Sonia Rodríguez-Fdez, XoséR. Bustelo and others: The Vav2-dependent pathway contributes to skeletal muscle growth and metabolic homeostasis. Nature Communications, 2020. doi 10.1038 / s41467-020-19489-z
Thanks to projects funded by the Ministry of Science and Innovation, the University Department, the Carlos III Institute of Health, the Spanish Anti-Cancer Association (AECC) and the Municipal Foundation of Castilla-León (Junta de Castilla-León), provided for this work Funds.