‘Twincretin’ Tirzepatide Gets FDA Approval for Type 2 Diabetes

The “Twincretin” era for treating patients with type 2 diabetes has begun, with the US Food and Drug Administration’s (FDA’s) approval of tirzepatide for this indication on May 13, making it the first approved agent that works as a dual agonist for the two principal human incretins. Tirzepatide represents “an important advance in the treatment of type 2 diabetes,” said the FDA’s Patrick Archdeacon, MD, associate director of the Division of Diabetes, Lipid Disorders, and Obesity, in a statement released by the agency. That advance is based on tirzepatide’s engineering, which gives it agonist properties for both the glucagon-like peptide-1 (GLP-1) receptor, as well as the glucose-dependent insulinotropic polypeptide (GIP). Several agents are already approved for US use from the
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