The seroprevalence study conducted between March 2020 and May 2020 concluded that the number of reported infections in Wuhan is three times that of people without symptoms.
city of WuhanIn China, it is the first place in the world to report a case of covid-19. According to the authorities, it took four months from December to March to contain the virus. However, a new study conducted between March and May concluded that the city was inhabited by a “large number” of asymptomatic carriers in the following months.
The authors of the study warned: “SARS-CoV-2 can exist in people without clinical cases for a long time.” PLOS neglected tropical disease. “we estimate Thousands of people They pointed out that they had asymptomatic infections between March 6 and May 3, 2020. “
To perform this calculation, the researchers analyzed data from Serological analysis The study was conducted on returning to work after imprisoning healthy individuals nationwide. Of all the data they collected (63,107), most belonged to Hubei Province, and Wuhan was located in Hubei Province (49,257). The remaining samples (13,850) belong to the remaining provinces.
The rapid antibody test used to diagnose past and current SARS-CoV-2 infections detects two types of antibodies: Immunoglobulin, Indicating that you have been infected with a virus before, and Immunoglobulin, Which means current or recent infection.
Among all individuals in the country, 465 were detected by IgG or IgM antibodies, a rate of 0.74%.412 of them belong to provincia de Hubei, The ratio is 0.84%.
In the 17 regions studied in Hubei Province, nearly half of the seropositive workers (186 workers) came from Wuhan.
Considering the large number of antibodies they detected in Wuhan and Hubei Province, the researchers believe that they should further decompose the data and analyze them separately. Therefore, they excluded Wuhan’s data from the province’s results. Similarly, they did the same with the data of Hubei national results.
After extrapolating these two data, the SARS-CoV-2 corrected seroprevalence rate is 0.59% in Hubei (226/38,171) and 0.38% in China (53/13,850).
Research shows: “This shows that the SARS-CoV-2 seroprevalence rate in Wuhan is significantly higher than other cities in Hubei Province and other parts of China.
In Hubei Province, SARS-CoV-2 seropositive persons have been found in all cities except the Shennongjia area. Wuhan City and its surrounding cities have the highest seroprevalence rate.
In addition, according to the positive rate of IgM in Wuhan City of 0.46% (51/11,086), the researchers estimated Thousands of people in Wuhan have asymptomatic infections Between March 2020 and May 2020, no clinical cases of covid-19 have been reported.
“Based on the seroprevalence rate of 1.68% and the population of 10 million in Wuhan, we estimate 168,000 people were infected The study concluded that SARS-CoV-2 was associated with SARS-CoV-2 during the urban covid-19 epidemic, and pointed out that the official number only reported 50,340 cases of covid-19 patients. The text added: “At least two-thirds of the infected people in the city are asymptomatic.”
According to scientists, these results indicate that there are asymptomatic carriers of SARS-CoV-2 in large areas of China, and many people in Wuhan are asymptomatic carriers of SARS-CoV-2.
Qin Xin, wait. “The seroprevalence of SARS-CoV-2 and the status of asymptomatic carriers in Wuhan and other parts of China.” PLoS Negl said too much (2021).