A group of researchers have trained and developed A small amount of brain tissue, called organoids, By 3D printing chips A study Published in the magazine this Tuesday Biological microfluidics.
For this research, scientists from the Massachusetts Institute of Technology (MIT) and the Indian Institute of Technology in Madras used 3D printing to create Adaptable and reusable platform.
The structure has pores and microfluidic channels that allow organoids to grow, and can be used for Provide necessary nutrients and calories Promote the development of brain tissue.
For printing, the scientists used Biocompatible resin, used in dental surgery, Print the chip and sterilize it with ultraviolet light.
then They placed living cells in the crevices The tiny platform is sealed with a glass panel.
Until now, observe the growth of organoids Used a culture plate with many wells, Place them on the glass bottom under the microscope.
However, this board is expensive and is not compatible with all microscopes No nutrient circulation allowed On the fabric.
Ikram Khan, one of the study authors, emphasized Low cost using 3D printing And pointed out that this method also has other advantages, such as Easy to clean chips Use distilled water, and it turns out to be reusable.
Researchers conducted experiments with organoids derived from human cells and observed their growth through a microscope. They tracked its development for 7 days.
That piece of cloth Eventually a cavity or ventricle surrounded by a self-organizing structure is formed Similar to the neocortex of the brain.