The newly formed embryo optimizes its survival by destroying defective cells.This summarizes the recently published paper, which was published in natural, Which may promote new clinical trials to treat infertility or miscarriage.
The team from the Center for Genome Regulation (CRG)Find Embryo Newly formed people pass Remove defective batteries. According to the researchers, Innate immune response It was first discovered in vertebrates so far.
The findings are published in this week’s journal natural, Can help you understand why certain embryos are Early stage of development And promote new clinical research to treat Infertility Go Spontaneous abortion.
Embryos are fragile in the first few hours after formation.Fast Cell division with Environmental pressure Make them easy to accumulate Cell errorThis leads to the sporadic death of embryonic stem cells. For experts, this is one of the main causes of preimplantation development problems.
Living organisms can use immune cells to kill defective cells, and immune cells can perform this function. However, newly formed embryos cannot yet produce these specialized cells.
Find out if embryos can kill cells that die in the absence of cells immune system, The team used a high-resolution microscope to record Zebrafish and mouse embryos, Has established two scientific models for studying vertebrate development.
Therefore, they found Epithelial Cells -Together to form the first tissue on the surface of the embryo-defective cells can be identified, taken up and destroyed. This is the first demonstration that this biological process (called epithelial phagocytosis) can eliminate cellular errors in newly formed embryos.
He said: “Long before the formation of organs, one of the first tasks performed by the developing embryo is to create protective tissues.” Esteban Hoijman, The researcher and the co-author of the study.
Cell “scavenger” to eliminate defects
As Hoijman explained, due to the presence of arm-like protrusions on the surface of epithelial cells, epithelial phagocytosis is a very effective process. “They cooperate mechanically; we found that epithelial cells push defective cells to other epithelial cells, thus speeding up their elimination.”
He said: “Our research provides a new function for epithelial cells in the early stages of embryogenesis, which has been evolutionarily conserved in vertebrates: they act as a scavenger to remove dead cells.” Verena Ruprecht, CRG researcher and lead author of this article. “This work may have important clinical applications in the future, such as the development of new methods to assess the quality of embryos in reproductive medicine.”
For the author, the discovery that embryos have an immune response earlier than previously thought has prompted people to further explore the role of mechanical cooperation as a physiological function in tissues, which is still not well understood. They concluded: “In other biological processes, such as homeostasis and tissue inflammation, this can be very important.”
natural. DOI: 10.1038 / s41586-021-03200-3
This research was supported by the Spanish Ministry of Science and Innovation, the European Research Council, the Spanish Ministry of Economy and Competitiveness, the Severo Ochoa Excellence Program, the Cellex Foundation, the Mir-Puig Foundation, and the Comprehensive Government of Catalonia. CERCA Center Plan.