Juan Carlos Izpisua Belmonte directed the research, which produced embryos with monkey and human cells
The chimera is a fabulous monster that spit out flames and has a lion’s head, a goat’s abdomen, and a dragon’s tail. In biology, genetic mosaicism is related to this monster: it is an organism made up of cells with more than one different genotype.
In order to obtain chimeras in animals, two or more fertilized eggs of different species need to be mixed together. The result is that the animal has some cells of one genotype and other cells of another genotype.
An international team of researchers led by Spanish researcher Juan Carlos Izpisua Belmonte successfully preserved embryos composed of human and monkey cells in petri dishes.This scientist has published his research in the El País newspaper in 2019, and now Published scientific papers in the famous “Cell” magazine All the details.
Izpisua Belmonte belongs to the Salk Institute of La Jolla (California) in La Jolla (Salka). In their experiments, they created a total of 132 monkey-human chimeras, of which 103 days were still alive after 10 days, and 103 were still alive. For this, they obtained embryos from Javanese monkeys and injected them with human so-called expanded pluripotent stem cells (hEPSC).
This research is important because until now, attempts to keep human and animal cells intact in the embryo have failed.
The purpose of this research is to study embryo development and better understand the interactions between genetically disparate cells. To this end, researchers from the US-China research team analyzed which signals are being exchanged and compared them with the signal chains of pure human and pure monkey embryos.
The main goal of hybrid biology research is to grow human organs in animals (such as pigs) for transplantation. According to experts, current research provides information on how to improve the survival of human cells in pigs or other animals, for example, how to grow donor kidneys or pancreas in the future.
This research is important because until now, attempts to keep human and animal cells intact in the embryo have failed. However, the genetic proximity between humans and monkeys makes this type of experiment ethically controversial.
Especially in monkey research, it is necessary to ensure that the target is not the birth of a hybrid under any circumstances, and this embryo must be implanted into a human surrogate mother.
However, the genetic relationship between humans and Javanese monkeys is likely to be the reason why embryos survive so long in culture. At the same time, this may also mean that the birth of this chimera is possible.
If this animal was born, what would it be like? If human cells stay in the developing brain or chimeric gametes, there may be consequences. Experts said that in order to avoid such cases, clear legal norms and international consensus on their application are needed.