The author from the Spanish Academy of Neurology emphasized the importance of continuing to monitor possible vaccine-related events. They believe that although mass vaccination is extremely important, they have decided to stop vaccination until we are more “cautious” and “will enable vaccinated people to obtain more and better information.”
The European Medicines Agency has not yet observed a clear link between the AstraZeneca vaccine and thrombosis, but in general, it does recognize a slight increase in cases of diffuse intravascular coagulation and cerebral venous sinus thrombosis. It is important to monitor the situation to ensure that the number of cases observed is similar to the expected number of cases.Real-time assessment of possible vaccine-related events is very important. Although a lot of effort is required, it can still ensure Safety of vaccinators.
Frequency of Cerebral Venous Sinus Thrombosis In the general population, there are usually fewer than two cases per 100,000 people per year. The number of cases that caused a pharmacovigilance alert was slightly higher, but given its importance, it was decided to analyze the available information and even temporarily suspend vaccination until more information is obtained.
Main road blocked
Venous sinus thrombosis is a disease in which the key event is the obstruction of venous blood flow caused by acute obstruction caused by thrombosis. The consequence can be equivalent to blocking the main road, so first, blood will accumulate in a retrograde manner, which will lead to increased blood lipids. Intracranial pressure, Causing headaches or visual disturbances and other symptoms.
Real-time assessment of possible events related to the vaccine is essential, which makes it possible to ensure those who are vaccinated.
If the obstruction persists over time, it prevents the supply of oxygenated blood to the area near the obstruction, resulting in Ischemia Affected territory. In the car metaphor, this would be an obstacle to the trucks equipped with spare parts to reach their destinations, leading to a lack of resource contributions.
Human blood has a certain tendency to promote blood coagulation, so as to avoid excessive bleeding in case of injury. The mechanism of thrombosis may be related to the damage to the vascular endothelial wall. Conditions that cause blood flow to slow down, which may lead to platelet aggregation and other circulatory system components; or have diseases or conditions that suggest a thrombotic state, such as certain cancers, severe infections, high-dose use of female hormones, pregnancy or certain Diseases of the blood system.
In many patients, these conditions are not present at the time of thrombosis, but subsequent extensive research is crucial because the treatment may vary from disease to disease.
Low platelet count
One Abnormally low platelet count Patients with cerebral venous thrombosis are temporally related to the use of AstraZeneca vaccine for immunization. The mechanism by which this happens is still unknown, and the theory is based on the assumptions of different experts. Theoretically, this may be caused by the activation of platelets related to the immune process, leading to their aggregation and thus reducing the number of platelets in the circulation.
Like other diseases that affect the brain, the clinical manifestations of cerebral venous sinus thrombosis are not always the same. This is a dynamic process whose symptoms depend on the state of thrombosis at the intracranial level and its consequences.
The most common symptoms are headache. Most patients with this disease have some atypical data that can distinguish it from other causes of headaches. When the intracranial pressure increases, the headache is usually exacerbated by keeping the head at the same level as the rest of the body (ie lying down). Sometimes blurred vision occurs, which is caused by the increased pressure transmitted through the optic nerve sheath.
In more severe cases, insufficient arterial blood supply can cause ischemia in the area, which can lead to venous infarctions and even cerebral hemorrhage within these infarcts. When this happens, patients may suffer from neurological symptoms, such as localized and sustained intensity drops, loss of half-body sensation or low level of consciousness, or seizures in a small number of patients.
It is important that patients and medical staff understand the situation of venous sinus thrombosis in order to detect and treat it as soon as possible
Suspicion is important for its correct diagnosis, because it may be invisible in traditional brain imaging techniques. In order to diagnose it, it is usually necessary to compare and execute a specific sequence to study the venous system. The key to its treatment is to restore cerebral blood flow, which can promote the restoration of cerebral blood flow through drugs that help thrombus degradation.
Given the potential severity of this adverse effect, monitor Possible circumstances and Epidemiological surveillance More important than ever. It is important that both patients and medical staff must be aware of the different ways of venous sinus thrombosis in order to detect it as soon as possible and treat it in a specific way.
Although mass vaccination of the population is extremely important, the decision to stop vaccination before obtaining more information and take a coordinated decision across Europe is not an easy task, but it should be a prudent decision that allows people to use more information. More and better information for vaccination.
Neurologist Dr. José Miguel Láinez. President of the Spanish Society of Neurology.
Neurologist Dr. David García Azorín. Member of the Spanish Academy of Neurology.