Mitochondria, which provide most of the energy for cell activities, become dysfunctional during space travel. This is the conclusion of an international research team that explored how cells respond to this situation, the results of which may have an impact on cancer research on the planet.
As space exploration continues, Biological research Space flight is essential for understanding how space systems and space exploration affect living systems including human health.
According to investigations by several US centers, studies on mice and humans entering space indicate that mitochondria, a key part of the cell’s energy production mechanism, may be dysfunctional due to changes in gravity, radiation exposure, and other factors.
This discovery is part of extensive research work across various scientific fields, with the goal of understanding the health effects of this drug. Space travelling. By broadening our understanding of these metabolic changes, this work has implications for future projects and medicine on the planet.
“The research work of our group focused on the muscle tissue of mice sent into space and compared them with the analysis of other scientists who study different tissues in mice. Although each of us has studied different tissues, we have all concluded The same conclusion: Mitochondrial function Are negatively affected by space travel,” he said Evagelia C. Laiakis, Associate Professor of Oncology, Lombard Comprehensive Cancer Center, Georgetown University, USA, and co-author of the study cell.
In addition to studying the effects of space travel on cell function, scientists also used data from decades of human flight experiments. NASA Compare their results in animals with 59 astronauts.
They can also access NASA data from biological samples that have flown into space for other comparisons. NASA twin data Mark y Scott Kelly They are particularly useful because they can compare the health effects of astronaut Scott in space with his brother Mark on Earth, the latter being a retired astronaut.
By comparing human data with the work of mice, Layakis and his team were able to determine that space travel caused certain MetabolismFor example, liver changes are more obvious than other organs, and mitochondrial function is impaired.
Graphical summary of the study. / Cell
Another concern about the future of Mars exploration
Since space travel almost always exposes people to higher levels of radiation than on Earth, scientists know that this type of radiation can damage mitochondria.
Armed with knowledge of the effects of radiation on these organelles, clinical cancer research on Earth can customize radiation therapy in the future to better protect tissues.
This study Journey to MarsBecause they take longer in space, they will be exposed to radiation for a long time, which is a problem that researchers are concerned about.
“Earlier this month, SpaceX’s launch was very exciting. From here, there are other adventures planned in Luna Eventually on Mars, we hope to learn more about the effects of space flight on metabolism and how to potentially mitigate the adverse effects on future space travelers,” Laakis concluded.
This work was published at the same time as Cell report, cell system, pattern and science Other risks related to human health caused by space travel.
CSIC’s participation in Spain
The Advanced Scientific Research Council (CSIC) participated in some of these studies, which led a European team funded by the European Space Agency (ESA) to coordinate use Big Data Biological research in space exploration and colonization.
The team has been using GeneLab tools NASA, which collects biological information Omics ScienceThose genes that involve the entire genome include genomics, proteomics, epigenomics, transcriptomics, and metabolomics, as well as samples from spatial experiments.
Refers to the purpose of something Big Data Research in space biological sciences will help reveal the effects of space Molecular level In the biological field, it is a key development in future long-distance space exploration.
“Due to the adoption of new sequencing technologies, many molecular biology experiments (such as mitochondrial experiments) will generate large databases, because so far, due to the technical limitations of space research, large databases (big data) cannot be used,” pointed out Raul Herranz, A researcher at the Margarita Salas Center for Biological Research (CIB-CSIC), and the coordinator of a European project called Space Omics.
Herranz is also a global consortium “International Space Omics Processing Standard” (ISSOP) To define the standards for using and processing large amounts of data obtained in experiments in space and on Earth over the years. These standards are also published today in the journal mode.
Silveira et al. “Multi-omics analysis shows that mitochondrial stress is the central hub of the biological impact of space biology,” cell.