Ultrasound scanning allows the use of ultrasound to “see” internal structures, while gamma-ray imaging can provide information on the metabolism of radiotracers injected into the patient’s body. Now, researchers from the Institute of Particle Physics have developed a prototype that combines these two technologies to improve the accuracy of biopsy and personalize the treatment of any type of cancer.
Scientist from Institute of Particle Physics (International Finance Corporation, The hybrid center of CSIC and the University of Valencia) has achieved Guided biopsy It can be directly applied to any type of cancer that requires biopsy and ultrasound examination in real time.
Cancer tumors are not homogeneous, but have heterogeneity and larger aggressive areas. Therefore, in order to perform effective processing, samples must be collected in the most representative area.
The device can guide the biopsy needle to the area with the greatest tumor activity. Combine gamma imaging with ultrasoundIn other words, it adds the metabolic information provided by the former from the radioactive tracer injected into the patient with the morphological data provided by the ultrasound or ultrasound machine.
As mentioned before Luis CaballeroThe IFIC scientist in charge of the study said: “Currently, the only way to obtain this metabolic information is to inject the patient Radioactive tracerIt is a substance with radioactive isotopes that emits gamma rays when it decays.”
This radioisotope attached to glucose is mainly absorbed by cancer cells because its high replication rate requires high energy consumption. Fundamentally speaking, they are extracted from glucose.
Therefore, “images of the distribution of radiotracers obtained from gamma rays provide information about activity within the tumor,” Cavallero said.Integrate this Metabolism into morphological informationThe results provided by ultrasound used to guide breast cancer biopsy will allow samples to be taken from the most active areas of the tumor, thus improving the accuracy of the process and personalizing the patient’s treatment.
“There is no such system on the market. Three advantages“Because of its accuracy, it can be personalized for cancer treatment, reducing the number of biopsies, and its design allows it to adapt to different current ultrasound systems, thus reducing costs and helping to insert it into the market.” Researcher .
The types of companies that may be interested in this patent are companies that have commercialized ultrasound systems and want to incorporate this molecular imaging technology, and companies that are committed to molecular imaging in the nuclear medicine field.
The equipment already has an international PCT (Patent Cooperation Treaty) application, which has entered the national phase of the United States, Japan and Australia. “The goal is to license technology or establish a company get rid of And become the promoter of the equipment,” Caballero pointed out, his team received financial support from the University of Valencia and General Valesiana.
In addition to its application in biopsy guidance, this technique also opens up new perspectives for techniques used in surgery. Nuclear medicine For example, in a recent technique that greatly improves the prognosis, the technique involves inserting radioactive seeds into sentinel lymph nodes to label the ganglia themselves for identification after neoadjuvant chemotherapy.
“This technology can be executed and controlled by the gamma image provided by our system, because it is possible to supervise the deposition of seeds and to ensure that they are deposited in the outpost node instead of another node,” the investigator concluded.