Researchers in the Child Leukemia Research Classroom Anti-leukemia hero Lead a study to identify new Biomarkers It may have clinical use in the fight against childhood lymphocytic leukemia.
Leukemia is Childhood cancer The incidence is even higher, accounting for 30% of pediatric cancers, and Spain has 300 new cases each year.Most of the Pediatric Leukemia (80%) belong to Acute lymphocytic leukemia (ALL), this is the content of this article.
In this publication, the publication was mainly developed by the Genomics and Oncology Research Center of Pfizer University-Andalusia in Granada (Jian Yang), a sample of children from 1 to 12 years old who were treated at the Malaga Regional Hospital and the San Juan de Barcelona Hospital in Barcelona.
“In this research, we focused our attention on long non-coding RNAs, which are a gene that belongs to the most unknown part of our genome. They are genes that are difficult to study, but at the same time, they may be for understanding cancer, etc. The key to the complex process that occurs in the disease. Marta Cuadros, One of the main authors of the article.
The researchers studied the differences in the expression levels of 2,829 long non-coding RNAs between children’s ALL samples and healthy samples. To help predict the function of RNA, they associate each RNA with a protein-coding gene, which can be regulated by non-coding RNA.
“In this comparison, a gene pair consisting of the connective tissue growth factor gene (CCN2) and a long non-coding RNA close to this gene (called AL133346.1) is particularly abundant in tumor samples.” Alvaro Andrades, One of the main authors of the study.
Towards a better prognosis
The research results show diagnosis The relationship between the product of connective tissue growth factor and AL133346.1 on acute lymphoblastic leukemia and healthy specimens and other different types of leukemia. This makes it useful as a disease biomarker.
In addition, when the sample for the study of connective tissue growth factor products is larger, it belongs to the League of Nations Research that produces effective treatment in treatment, It was found that patients with a higher amount of the gene product had a longer survival period, which confirmed its usefulness as a prognostic biomarker for this type of childhood leukemia.
He concluded: “We hope that the research classroom will continue to contribute to the study of childhood leukemia and the importance of bone marrow donation to the prevention and treatment of this disease.” Pedro Pablo Medina Vico, Director of the Child Leukemia Research Classroom, Professor of the First Department of Biochemistry and Molecular Biology at the Faculty of Sciences of the University of Granada, and Chief Researcher of GenyO and the Granada Institute of Biological Health.
Today, Monday, February 15 International Childhood Cancer Day The goal is to raise society’s awareness of this disease and to increase the need for proper diagnosis and treatment of all children suffering from cancer in the world.
Marta Cuadros Wait. “LncRNA-mRNA co-expression analysis identified AL133346.1/CCN2 as a biomarker in pediatric B-cell acute lymphoblastic leukemia. ” cancer