A vaccine against covid-19 is a great hope for this pandemic.Millions of people are paying attention to the emergence of antidote, which allows us to return to normal, including the mother of a virologist Isabel Sola (San Adrián, Navarra, 1967). The National Center for Biotechnology (CNB-CSIC) explained: “And it’s impossible to give it to them right away, because it’s impossible, so sometimes even if you know you’re doing everything possible, you’ll feel a little disappointed.”
Rear Coronavirus research has been 25 years, She is one of the people in Spain who knows these pathogens best, although the statement seems to bother her: “We may know more about the coronavirus, but the fact is that almost anyone in society has received this disease. Accelerated. course”. His speech is humble, slow, and very insightful. “I always wanted to know why… how things went,” he said of his curiosity.
Sola’s laboratory is jointly led by him and Spanish virologist Luis Enjuanes. It is one of the three teams of the Advanced Scientific Research Council (CSIC) that is developing a vaccine against covid-19.For their part, they have experience in designing vaccine prototypes against previous coronaviruses, such as SARS with Marketing Department, But those candidates still remain in the drawer: “The imminent danger has disappeared, and all the funds have disappeared.”
But Sola went further and was critical of this short-term scientific investment view: “We don’t know that the coronavirus is an emerging virus with pandemic potential and has the ability to reappear. It is not necessarily the same, but has other Another attribute of a specific attribute, but this will share a lot of things we already know, precisely because it belongs to the family.
Previous research and knowledge of previous coronaviruses now provide them with certain advantages. The SARS-CoV-2 virus that causes covid-19 is 80% identical to SARS-1 that appeared in China in 2002. But Sola emphasized that 20% of its sequences are unique: “Unlike other coronaviruses, it has a wide range of severity. In some cases, the symptoms are not very severe, the symptoms are very mild, and some cases are very severe. Serious and cause death”.
Dozens of candidates for a single disease
According to the World Health Organization, there are about 200 vaccine candidates in the world tracking device Representative of the World Health Organization (WHO). Isabel believes that this diversity is “rich” as long as it diversifies “a certain amount of common sense.” Therefore, he advocated supporting different projects at the same time.
As Sola explained, if we visualize the idea of finding a vaccine as an attack on the enemy, there are multiple ways to attack it from different sides. He said: “Some of them may be ineffective, others will be effective, and even within those effective and safe ranges, everyone can be effective against a certain group of people.”
Among dozens of candidate vaccines, there are four good ways to obtain a vaccine.
The most classic method is from Whole virusSuch as influenza or measles vaccine.
Another option is from Other viruses that act as intermediaries The genetic material of SARS-CoV-2, such as CNB-CSIC’s Mariano Esteban group project or Oxford University’s project and American pharmaceutical company AstraZeneca, are passing Adenovirus chimpanzee.
The other two formulas are designed on the one hand, From its protein Or, on the other hand, genetic material, Moderna, Pfizer and the laboratories of Isabel Sola and Luis Enjuanes.
The prototype of the group led by Sola is a simplified version and a reduced version of SARS-CoV-2. This is because they eliminated all harmful elements with the help of gene editing technology invented in his laboratory twenty years ago. acquired. Virus, and only has the necessary ingredients to prepare for an immune response.According to virologists, the two advantages of her candidate are You only need one dose and provide More complete and lasting response.
This is the process followed by the Solai Enjuanes laboratory for the development of vaccines. Infographic: Jose Antonio Peñas of SINC.
This vaccine race has fueled Populism of political leadersLike Donald Trump or Vladimir Putin, even the WHO has sounded shocked at the worrying rise of nationalism. The virus does not understand national borders or ideologies. Understanding protection as the fall of my small country… This is a pandemic! The pandemic has affected the entire world,” Sola said loudly.
Another problem in this health crisis is Reluctance to get vaccinated The reasons for this include the speed of the process, the secrecy of certain candidates’ development, and the conspiracy theories inspired by the anti-vaccine. “If we don’t trust vaccines, what are the options? Do we want to continue to live like we do now?
They told her that at home, her child suffered because of her: “You must be careful, there are risk factors.” The head of the laboratory has bronchiectasis in the lungs, but she lives a completely normal life. She said: “In the face of a respiratory infection, you realize that you must take care of your body.” Although she admits that she usually does not think about this disease for herself, but for those around her. She said sincerely: “My children have not’flyed away’. They have no autonomy. You will find that you are still what they need.”
Vaccines are the best strategy to control any infectious disease and prevent infection, but its development requires years of research. The fastest design is the Ebola virus, which took only five years, but the spread of HIV has not yet been achieved. Virologists are aware of this: “This is a long distance race. If you work hard, this will not happen in a few months. The development of vaccines is much more expensive.”