Scientists have developed a transplantable hydrogel chip with ovarian cells, which can significantly improve endocrine function after menopause.
After removing the ovaries, the chip has been tested in rats.
The results show that this method can prevent problems caused by female menopause, such as weight gain and osteoporosis, while avoiding the potentially dangerous side effects of existing treatments (such as hormone therapy).
Menopause is often accompanied by symptoms that may put women’s health at risk, such as osteoporosis and cardiovascular disease.
New methods are needed to treat the effects of menopause
As it has been shown that the standard treatment for menopause, systemic hormone therapy, increases the risk of breast cancer, deep vein thrombosis, stroke and coronary artery disease, there is an urgent need for alternative methods.
In order to investigate whether an implantable chip containing ovarian cells might be a viable option, Hyo-Jin Yoon and his colleagues removed the ovaries from the rat ovaries, collected the cells from the ovaries, and then implanted them in the hydrogel hind legs.
In the course of 30 days, the plasma hormone levels of rats with ovarian cell hydrogel chips were comparable to those of rats with intact ovaries, and after 7 weeks, the endometrium or endometrium regenerated in the cells. .
Unlike rats treated with estradiol or estradiol-progesterone combination hormones, rats treated with ovarian cell chips did not experience endometrial hyperplasia (a potential cause of uterine cancer) or increased deep vein thrombosis , Supporting its potential as a standard hormone replacement. treatment.
In addition, rats with hydrogel chips showed comparable body weight and fat percentage to rats with intact ovaries.The article has been published in Scientific progress.
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