Scientists in Israel, Spain and other countries have created a device that can measure the current through DNA, which makes it possible to discover how it conducts current over long distances. This discovery opened the door to a new generation of DNA-based nanoelectronic devices.
The increasing need to reduce the size of electronic devices has led scientists around the world to explore the possibility of using individual molecules as their building blocks.In the past two decades, even using DNA molecule As a cable, use its extraordinary identification and self-assembly characteristics.
However, the experiments conducted so far have shown conflicting results, which makes it difficult to understand how to conduct current through DNA and whether this small double-strand may become the basis of a new generation of electronic nanodevices.The main problem lies in the huge technical challenges of the manufacturing industry Reproducibly Circuit based on a single DNA molecule.
But now, a multidisciplinary team consists of people from Jerusalem, Tel Aviv, Michigan, Cyprus, Seville and Autonomous Community of Madrid (UAM)In other centers, the company has managed to create a device that can measure the current through DNA in a repeatable manner.
Therefore, with the help of this system, scientists finally managed to reveal the physical mechanism by which the molecule can conduct current over long distances.
Found, published in a magazine Nature Nanotechnology, Reignited development DNA-based nanoelectronics, And may lead to the development of new ultra-sensitive and ultra-fast sensors to detect cancer and various pathogens.
The team’s first task is to synthesize a new type of molecular structure in which a single DNA molecule is Gold nanoparticles. In the second phase, the researchers developed a method based on a non-uniform electric field to capture these structures (or dimers) between two metal electrodes previously defined using standard electronic lithography techniques.
“In this way, manufacturing can be done in a repeatable manner Electronic nanocircuit All current flows through a DNA molecule, and its structure or sequence can be chosen at will”, the co-author explained Juan Carlos CuevasResearcher of UAM Condensed Matter Theoretical Physics Department.
He added: “In this way, we proved that DNA molecules can conduct electricity over long distances, which is the basic requirement for them to be part of it. Electronic equipment. In addition, with the help of theoretical simulations, we understand the ins and outs of the physical mechanisms that make these molecules conduct current, which has fundamental significance in such disciplines as biology, physics, and chemistry.
This group of authors believes that their findings also have great technical significance, because the experimental techniques introduced in this work may be the basis for the development of new types of ribosomes. Sensor Bioelectricity Detect specific DNA or RNA fragments in saliva or blood in an ultra-fast and ultra-sensitive way.
“This may completely change the virusThe researchers concluded that due to current methods such as PCR (polymerase chain reaction), the method is relatively slow and requires a large amount of these nucleic acids.
R. Zurravel, H. Huang, G. Polycarpou, S. Polydorides, P. Motamarri, L. Katrivas, D. Boo 2020. “Backbone charge transport in double-stranded DNA”. Nature Nanotechnology, 2020. DOI: 10.1038 / s41565-020-0741-2.