Spanish researchers discovered that dendritic cells have the ability to reprogram their genes, thereby improving their immune response.The work was published in Scientific progressIt may have important applications in the development of new vaccination and immunotherapy strategies.
Scientists of the National Center for Cardiovascular Research (China Internet Network Information Center), led by Francisco Sanchez Madrid,show Dendritic Cells -Responsible for startup immune response Specific-has the ability to reprogram its genes, thereby increasing its antiviral ability and activating the response.
The results of this research were funded by the “la Caixa” Foundation and published today in Scientific progress, May have important applications when developing new strategies Vaccination and immunotherapy, Because the described mechanism can be used to generate hyper-migrating postsynaptic dendritic cells, thereby inducing more powerful and efficient replication.
Dendritic cells are specialized antigen-presenting cells that initiate adaptive or specific immune responses. These cells capture possible pathogens in different tissues and entry pathways, process them and transport them to the lymph nodes.
“There, communication with T lymphocytes is established by organizing a special structure called’immune synapse’. Through this structure, dendritic cells’display’ the processing of various infectious factors of T lymphocytes. Ingredients so that CNIC researchers explained: “We have realized that T cells can initiate and carry out a specific immune response against this agent.”
So far, it is believed that the function of these dendritic cells is limited to the activation of T lymphocytes, but the research team of Sánchez-Madrid Almudena R. RamiroIt has been found that during the formation of immune synapses, dendritic cells also receive information from T lymphocytes.
Sánchez-Madrid said: “Therefore, they instructed and induced them to change the gene expression program, thereby increasing those genes related to migration, antiviral response and molecular secretion, thereby enhancing their ability to generate protective immune responses against pathogens. .”
After effective synaptic contact with T lymphocytes, dendritic cells increase their mobility (green synaptic cell pathway and red non-synaptic cells). / CNIC
Optimize immune response
Researchers found that after the occurrence of immune synapses, the migration of dendritic cells to lymph nodes is more “effective”, where most of the processes that activate specific or adaptive immune responses are produced in lymph nodes.
They pointed out: “This work describes how changes in gene expression are accompanied by changes in DNA epigenetic marks, and the changes in epigenetic marks produce transient mutations in specific genes, which promote or hinder their expression. .” Irene Fernandez Delgado ÿ Diego Calzada Fraile, The main author of the study.
They added that, in particular, “one of the genes that increases its expression and accessibility is Ccr7, a cell migration receptor that is located on the surface of dendritic cells and directs them to the lymph nodes.”
This study showed that after dendritic cells interact with T lymphocytes, genes are reprogrammed through epigenetic marks in DNA. “The scientist came to a conclusion.
Alcaraz-Serna, F. Sánchez-Madrid et al.: Immune synapses indicate reprogramming of epigenome and transcriptome functions in dendritic cells. Advanced science. 7, eabb9965 (2021)
This research was funded by the “la Caixa” Foundation through an appeal for funding from the “Health Research Project” HR17-00016 and INPhINIT to “reserve” the PhD.