The International Mouse Phenotyping Consortium (International Mouse Phenotyping Consortium) proposed the first batch of mouse radiology atlases, which will enable people to better understand and establish the phenotypes of human disease models. This document was prepared by the international PATHBIO project led by a researcher from the Autonomous University of Barcelona.
Researchers from the Autonomous University of Barcelona (UAB) and the MRC Harwell Institute have developed a new Mouse Radiology Atlas, Within the following frame International Mouse Phenotyping Federation (IMPC) and is part of the European PATHBIO project led by a professor from the European Veterinary College, Jesus Rupert.
Research centers and other similar research institutions that are members of the IMPC Alliance can produce the following images: X-ray film Lots of mice. Currently, about 250,000 radiographic images have been generated. Researchers need to analyze each image to correctly diagnose the phenotype of the mouse.
The new atlas provides guide In the depths analysis skeleton Mice used as models for studying human diseases. It is a very important resource for novice researchers in the field of phenotyping and experienced researchers seeking to improve their ability to observe and recognize changes in mouse bones.
Atlas includes 152 X-ray images, 16 original images with 590 anatomical landmarks. It also explores the obvious skeletal differences between men and women. According to the standard IMPC phenotype research protocol, X-ray image examination was performed in 14-week-old C57BL/6N mice.
The main goal of the European PATHBIO (Precision Pathological Biology of Disease Models) project on mouse models of human diseases led by Ruberte is to implement an integrated European approach to improve the performance of researchers using mouse models. Education and training to determine new technologies and knowledge in new fields.
PATHBIO is the first European Erasmus + Knowledge Alliances project led by UAB. It is coordinated by Jesús Ruberte, a professor in the Department of Animal Health and Anatomy at UAB.
The PATHBIO consortium consists of 23 members, including leading European universities (Cambridge, Sheffield, Copenhagen, Lisbon, Naples), European Center of Excellence in Mouse Research (Helmholtz Zentrum, Medical Reserach Center, Clinic de la Souris Institute, Molecular Genetics) Institute), a company dedicated to the production of mouse models of human diseases (Jackson Laboratory, Toronto Phenotype Genomics Center, Charles River Laboratory) and a global network of non-European members (Instituto Pasteur Montevideo, Australian Phenotype Research) , Korea Mouse Phenotype Research Center, etc.).