A new study was published in Natural medicine To increase the understanding of human endometrial function, the embryonic uterus is the implant of the endometrium. Infertility, endometriosis, pre-eclampsia or endometrial cancer are some diseases that can progress after discovery.
Researchers from the Igenomix Foundation-INCLIVE,versus Stanford University with Chan Zuckerberg Biohub (Both in the U.S.), decoded for the first time Human endometrium, The mucosa uterus Where does the embryo start to implant Pregnancy. This discovery, Published in the previous issue Magazine Natural medicineImprove understanding of uterine function and its impact on uterine health Ms.
In the words of the research leader, Carlos Simon And Felipe Vilella, Yes Cell decoding “Stones in the endometrium are rosettes for understanding the function of this important reproductive organ.”The author affirms that this work will give the medical and scientific communities an opportunity to “better understand the pathology that causes the disease. Infertility In the womb”.
This new study reveals for the first time the behavior of each type of endometrial cell Menstrual cycle And the relationship between them. “Now that we know the cell behavior of the endometrium, this provides a huge opportunity to understand the unknown aspects of the disease, such as Endometriosis, This Preeclampsia, The implant failed or cancer Endometrium”, Simon explained.
Although the human endometrium is of great significance, especially in the reproductive stage of women, the understanding of the function of this organ is still limited. Therefore, the researchers set out to study the functions of the different cell types that make up the entire menstrual cycle.
To this end, they analyzed the expression of their genes by isolating a single cell in a single cell. 73,180 cells Obtained from the endometrium of 27 healthy women of childbearing age. The study revealed the dynamic changes of cell processes during the menstrual cycle.The endometrium is mainly composed of Six cell types, One of which was found in the study: ciliated epithelial cells.
The different stages of the menstrual cycle. / Includes
How this discovery improves reproductive success
Experts also determined when and how Implant windowThis is the only time when the endometrium is ready to start pregnancy. Vilella said: “In addition to the cell pattern, one of the major discoveries of this work is the discovery of the mechanism of the embryo implantation window.”
He added: “We have observed that it is immediately activated by the genes of the epithelial cells, and the genes of the epithelial cells will come into contact with the embryo at the beginning of pregnancy instead of gradually developing as previously thought.”
“Endometrial cells-from now on provide us with all the information about the ideal time to transfer embryos in embryo transfer therapy. Assisted reproduction-They can be obtained by liquid biopsy of the endometrium, so finding the implant window to know when the most acceptable moment will become easier, quicker and painless”, Simón continued.
The results revealed new knowledge about the function of the endometrium, the growth and organization of the different cells that form the endometrium, so that the organs can function normally during each menstrual cycle.
The authors concluded: “This discovery allows other scientists studying endometrial diseases to compare diseased cells with healthy cells, which can help develop new therapies or new drugs.”
Wang, W., Vilella, F., Alama, P. Wait. A single-cell transcriptome map of the human endometrium during the menstrual cycle. Nat Med 26, 1644–1653 (2020).