Patients treated with antipsychotics have a lower risk of contracting COVID-19, and if they do get the infection, they will get sick in a milder way.
Two investigations led by the Mental Health Department of Virgin Del Rocio University Hospital in the United States and researchers from the United States also participated in the investigation and concluded that antipsychotic drugs may have a protective effect against SARS-CoV-2.
Therefore, patients treated with these drugs have a lower risk of being infected, or if they are infected, they have a milder condition.
The first descriptive epidemiological study of 698 patients treated with antipsychotics in the Seville hospital showed that antipsychotics can both prevent infection and prevent the clinical severity of Covid-19 infection.
“This is a very interesting finding, and it does reflect the clinical reality. Although there are multiple risk factors, we rarely see patients with severe COVID-19 disease,” a clinical psychologist, the first of two works. One signatory Manuel Canal Rivero said. .
“In this group, the number of Covid-19 patients is lower than expected, and in the case of a confirmed infection, the evolution is benign and has not reached a life-threatening clinical situation. These data generally seem to indicate the protective effect of the drug “, he added.
As a supplement to this study, the same research team also observed that many genes whose expression has been altered by Covid-19 were significantly down-regulated by antipsychotic drugs, which are often used to treat diseases with psychotic symptoms.
This discovery can be achieved by studying the gene expression profiles (indicators of activated biological processes) of Covid-19 patients (Wuhan cohort) and patients receiving antipsychotic medications in the intervention program cohort (especially aripiprazole). (PAFIP) by Benedicto Crespo-Facorro, a professor at the University of Seville and the current director of the Mental Health Department of the University Hospital of the Virgen Rocio, Benedicto Crespo-Facorro at Marquis Valdédi in Cantabria 20 years ago La University Hospital started.
“The first author of the second method, Professor Crespo-Facorro, said: “We have shown in a surprising way how antipsychotics can reduce the activation of many inflammatory and immune pathways involved in the severity of Covid-19 infection. .
In addition, it highlights: “Although this is a discovery that needs to be replicated, this discovery may be of great significance because Covid-19 was treated with drugs that were originally used in unrelated clinical situations (ie, retargeting drugs). Proven to be an interesting source of effective treatment for Covid-19 patients”.
Two surveys Recently Published Among the journals with great influence in the international scientific community, they are co-led by researchers from the Translational Psychiatry Group of the Seville Institute of Biomedical Research of the Seville Institute of Biomedical Research (CIBERSAM) and IDIVAL (Santander) researchers . Researchers from the Institute of Infectious Diseases, University Hospital of Virgin del Rocío, Spain, from the Bioinformatics Department of the Nuclear Medicine Center of the University of Salamanca, and CSIC.
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